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MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) ADC Linker (1) Apoptosis (6) Arp2/3 Complex (2) Biochemical Assay Reagents (1) Bombesin Receptor (4) Bradykinin Receptor (1) Cathepsin (1) CFTR (3) Cholinesterase (ChE) (1) CRFR (5) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fluorescent Dye (1) Fungal (1) GLP Receptor (2) GnRH Receptor (6) HIV (1) HIV Protease (1) Influenza Virus (1) Integrin (5) Interleukin Related (1) JNK (1) Melanocortin Receptor (10) Neurokinin Receptor (4) Notch (1) Opioid Receptor (9) PAI-1 (1) PD-1/PD-L1 (1) Sodium Channel (1) Somatostatin Receptor (9) Thrombin (3) Tyrosinase (1) Vasopressin Receptor (3)
By Research Areas:	Cancer (37) Cardiovascular Disease (11) Endocrinology (12) Infection (4) Inflammation/Immunology (13) Metabolic Disease (7) Neurological Disease (24)

By Targets:

5-HT Receptor (1)

ADC Linker (1)

Apoptosis (6)

Arp2/3 Complex (2)

Biochemical Assay Reagents (1)

Bombesin Receptor (4)

Bradykinin Receptor (1)

Cathepsin (1)

CFTR (3)

Cholinesterase (ChE) (1)

CRFR (5)

DNA/RNA Synthesis (1)

Endogenous Metabolite (1)

Fluorescent Dye (1)

Fungal (1)

GLP Receptor (2)

GnRH Receptor (6)

HIV (1)

HIV Protease (1)

Influenza Virus (1)

Integrin (5)

Interleukin Related (1)

JNK (1)

Melanocortin Receptor (10)

Neurokinin Receptor (4)

Notch (1)

Opioid Receptor (9)

PAI-1 (1)

PD-1/PD-L1 (1)

Sodium Channel (1)

Somatostatin Receptor (9)

Thrombin (3)

Tyrosinase (1)

Vasopressin Receptor (3)

By Research Areas:

Cancer (37)

Cardiovascular Disease (11)

Endocrinology (12)

Infection (4)

Inflammation/Immunology (13)

Metabolic Disease (7)

Neurological Disease (24)

Inhibitors & Agonists

108

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1045

187-1, N-WASP inhibitor 1 Publications Verification	Arp2/3 Complex	Others
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-15664

Bivalirudin TFA

5+ Cited Publications

Thrombin Cardiovascular Disease

Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin.

Bivalirudin TFA 5+ Cited Publications	Thrombin	Cardiovascular Disease
Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin.

HY-131990A

*MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH*	ADC Linker	Cancer
MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-P1045A

187-1, N-WASP inhibitor TFA	Arp2/3 Complex	Others
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-P3666

[D-Phe2,6, Pro3]-LH-RH

GnRH Receptor Endocrinology

[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist .

[D-Phe2,6, Pro3]-LH-RH	GnRH Receptor	Endocrinology
[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist .

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P1929

Bivalirudin 5+ Cited Publications	Thrombin	Cardiovascular Disease
Bivalirudin, a peptide anticoagulant, is a direct thrombin inhibitor for anticoagulation in the setting of invasive cardiology, particularly percutaneous coronary intervention .

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P1107A

Antisauvagine-30 TFA aSvg-30 TFA	CRFR	Neurological Disease
Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF₂ receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a K_d of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively .

HY-P5265

Tetrapeptide	DNA/RNA Synthesis	Metabolic Disease
Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts .

HY-P1613A

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA Cyclo(RGDfV) TFA; C(RGDfV) TFA	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .

HY-105077A

Nemifitide diTFA INN 00835 diTFA	5-HT Receptor	Neurological Disease
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action . Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) . Nemifitide diTFA can cross the blood-brain barrier .

HY-P1185

Antagonist G	Vasopressin Receptor Apoptosis	Cancer
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .

HY-P1185A

Antagonist G TFA	Vasopressin Receptor Apoptosis	Cancer
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy .

HY-123275

H-D-Phe-Pip-Arg-pNA S-2238	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform .

HY-P1613

Cyclo(Arg-Gly-Asp-D-Phe-Val) Cyclo(RGDfV); C(RGDfV)	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .

HY-P3567

(p-Iodo-Phe7)-ACTH (4-10)	Melanocortin Receptor	Neurological Disease
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats .

HY-P4541

(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)	Bombesin Receptor	Cancer
(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) is a bombesin (BBN) antagonist and can be used for the research of cancer .

HY-P4561

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH	Cathepsin	Others
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis .

HY-122542

PPACK	PAI-1	Cardiovascular Disease
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-P5021

Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) c(RGDfE)	Biochemical Assay Reagents	Cancer
Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) (c(RGDfE)) is a cyclic RGD peptide that serves as a conjugated multifunctional nanodrug delivery system to target Gemcitabine to pancreatic cancer cells. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) can be used in cancer research .

HY-114437

Fusion Inhibitory Peptide Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication INHibitory Peptide	Influenza Virus	Infection
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein .

HY-P2028

BIM 21009

GnRH Receptor Cancer

BIM 21009 is a LHRH and GnRH receptor antagonist. BIM 21009 inhibits tumor growth .
HY-P0187

Senktide

1 Publications Verification

Neurokinin Receptor Neurological Disease Endocrinology

Senktide is a tachykinin NK₃ receptor agonist.

BIM 21009	GnRH Receptor	Cancer
BIM 21009 is a LHRH and GnRH receptor antagonist. BIM 21009 inhibits tumor growth .

Senktide 1 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
Senktide is a tachykinin NK₃ receptor agonist.

HY-P1714A

Apraglutide TFA FE 203799 TFA	GLP Receptor	Metabolic Disease
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .

HY-P1714

Apraglutide FE 203799	GLP Receptor	Metabolic Disease
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .

HY-P1106

K41498	CRFR	Cardiovascular Disease
K41498 is a potent and highly selective CRF2 receptor antagonist with K_i values of 0.66 nM, 0.62 nM and 425 nM for human CRF_2α, CRF_2β and CRF₁ receptors respectively. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF_2α- and hCRF_2β-expressing cells. K41498 can be used for hypotension study .

HY-P1106A

K41498 TFA	CFTR	Cardiovascular Disease
K41498 TFA is a potent and highly selective CRF2 receptor antagonist with K_i values of 0.66 nM, 0.62 nM and 425 nM for human CRF_2α, CRF_2β and CRF₁ receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF_2α- and hCRF_2β-expressing cells. K41498 TFA can be used for hypotension study .

HY-P1338

PL-017	Opioid Receptor	Neurological Disease
PL-017 is a potent and selective μ opioid receptor agonist with an IC₅₀ of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats .

HY-P1338A

PL-017 TFA	Opioid Receptor	Neurological Disease
PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC₅₀ of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats .

HY-P3659

(D-Phe7)-α-MSH

Melanocortin Receptor Cancer

(D-Phe7)-α-MSH is an α-MSH analogue .

(D-Phe7)-α-MSH	Melanocortin Receptor	Cancer
(D-Phe7)-α-MSH is an α-MSH analogue .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr) .

HY-103287

[D-Phe12,Leu14]-Bombesin

Bombesin Receptor Cancer

[D-Phe12,Leu14]-Bombesin is an antagonist of Bombesin Receptor. [D-Phe12,Leu14]-Bombesin can be used for the research of cancer .

[D-Phe12,Leu14]-Bombesin	Bombesin Receptor	Cancer
[D-Phe12,Leu14]-Bombesin is an antagonist of Bombesin Receptor. [D-Phe12,Leu14]-Bombesin can be used for the research of cancer .

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Tyrosinase	Cancer
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model .

HY-P4543

HIV-IN petide

HIV HIV Protease Infection

HIV-IN petide is a competitive inhibitor of HIV-1 protease (K_i=50 nM) .

HIV-IN petide	HIV HIV Protease	Infection
HIV-IN petide is a competitive inhibitor of HIV-1 protease (K_i=50 nM) .

HY-P5287

cRGDfK-thioacetyl ester	Integrin	Cancer
cRGDfK-thioacetyl ester is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for integrins. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging .

HY-P5053

Galacto-RGD

Integrin Cancer

Galacto-RGD is an RGD analogue that can be coupled with the radioactive isotope 18F and used as an integrin α₅β₃ selective tracer .

Galacto-RGD	Integrin	Cancer
Galacto-RGD is an RGD analogue that can be coupled with the radioactive isotope 18F and used as an integrin α₅β₃ selective tracer .

HY-P5287A

cRGDfK-thioacetyl ester TFA	Integrin	Cancer
cRGDfK-thioacetyl ester TFA is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for integrins. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging .

HY-N2466

Melanotan I 1 Publications Verification MT-I; [Nle4,D-Phe7]-α-MSH	Melanocortin Receptor	Neurological Disease Cancer
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction .

HY-P0210B

DAMGO TFA

3 Publications Verification

Opioid Receptor Cancer

DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a K_d of 3.46 nM for native μ-OPR .

DAMGO TFA 3 Publications Verification	Opioid Receptor	Cancer
DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a K_d of 3.46 nM for native μ-OPR .

HY-P0039

BIM-26226	Bombesin Receptor	Cancer
BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC₅₀s in the nanomolar range. BIM-26226 can be used for the research of cancer .

HY-P99004

hMC1R agonist 1	Melanocortin Receptor	Inflammation/Immunology
(EC₅₀=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC₅₀=902 nM), hMC4R (b>EC₅₀=915 nM), and hMC5R (b>EC₅₀=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family .

HY-N2466A

Melanotan I acetate MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate	Melanocortin Receptor	Cancer
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research .

HY-P3664

[D-Phe2,D-Ala6]-LH-RH Wy 18185	GnRH Receptor	Endocrinology
[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities .

HY-P2118

NPC-567	Bradykinin Receptor	Inflammation/Immunology
NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways .

HY-P4721

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)	Thrombin	Cardiovascular Disease
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a K_D < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM .

HY-P1329

CTOP	Opioid Receptor	Neurological Disease
CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity .

HY-P1329A

CTOP TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity .

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

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